AB0427 ANTI-NOR90 AUTOANTIBODIES: FAVORABLE OR UNFAVORABLE PROGNOSIS?

Background: Anti-NOR 90 autoantibodies (anti-NOR90 Ab) are that target nucleolar transcription factor 1 or hUBF, involved in of RNA polymerase I. These have been detected 6.1% patients with Systemic Sclerosis (SSc), but their clinical prognostic significance has not clearly defined. Anti-NOR90 Ab mostly associated limited scleroderma mild organ involvement and can also be found other rheumatic diseases such as rheumatoid arthritis, systemic lupus erythematosus Sjogren’s syndrome. Objectives: The aim this study was to identify the main characteristics positive anti-NOR90 our Centre. Methods: This is a retrospective, descriptive, cross-sectional all between January 2013 December 2020 single center. Autoantibodies testing performed using Euroimmun EUROLINE SSc profile IgG autoAb assay kit. Patient demographics, characteristics, diagnoses, laboratory immunological findings were collected. Results: We identified total 26 at least value for (Table 1). In most cases ANA positive, predominantly pattern coexisted autoantibodies. 12 had two SSc, both cutaneous absence involvement. 14 no definite diagnosis. Clinical features represented Figure 1. Five presented Raynaud’s phenomenon, pathological nailfold capillaroscopy one patient SSc. There skin ulcers, calcinosis, interstitial lung disease pulmonary hypertension. Four gastroesophageal reflux antral vascular ectasia. Six developed some neoplasm. patients. Conclusion: case series multiple heterogeneity manifestations. did observe further progression presence severe scleroderma, so these could related favorable prognosis. contrast previous reports, striking association cancer population. Table Demographic diagnoses Characteristics Total Anti-NOR90: Sex, n 19 women/ 7 men Age, mean (years) 58,9 IQR [46,3-72,2] Race, Asian: 1; Hispanic: 7; Caucasian: 18 Smoker, 3 Positive (>1/160), Pattern, 24 Homogeneous, 4 Nucleolar, Speckled, Centromere, 5 Speckled -nucleolar, Homogeneous-nucleolar. ENA, 2 Anti-SSA-Ro52 Ro60, anti-RNP anti-Sm sclerosisautoantibodies, •Anti-Ku: •Anti-U3RNP (Fibrilarin): 6 •Anti-RNA III: •Anti Th/To: •Anti-centromere: (CENP B +/- CENPA) •Anti-topoisomerase I: •Anti-Ro52: •Anti-PM-Scl: Main diagnosis, Rheumatic diseases: (2 limited/0 diffuse) arthritis LES Sjögren’s syndrome, undifferentiated conective tissue overlap (1 Sjögren + LES, MCTD 1) s: morphea, graft versus host Neoplasm, 6: solid (bladder, kidney), adenocarcinoma, myeloma, acute myeloid leukemia: basal cell carcinoma. Abbreviations: LES: erythematosus; MCTD: mixed connective Disclosure Interests: None declared